INNOVATIVE APPROACHES AND THERAPEUTIC AGENTS FOR THE TREATMENT OF BOVINE MASTITIS
DOI:
https://doi.org/10.30890/2567-5273.2025-38-02-045Keywords:
cows, mastitis, antibiotic administration, combined and infusion administration, non-steroid anti-inflammatory drugs.Abstract
It has been proven that antibiotic therapy continues to play a crucial role in the treatment of dairy cows, affected by mastitis. Antibiotics serve as the foundational component of therapeutic protocols.Two primary routes of antibiotic administration areMetrics
References
Boboš S., Radinović M., Vidić B., Pajić M., Vidić V., Galfi A. Mastitis therapy: Direct and indirect costs. Biotechnol. Anim. Husb. 2013;29:269–275. doi: 10.2298/BAH1302269B.
Ali T., Raziq A., Wazir I., Ullah R., Shah P., Ali M.I., Han B., Liu G. Prevalence of mastitis pathogens and antimicrobial susceptibility of isolates from cattle and buffaloes in Northwest of Pakistan. Front. Vet. Sci. 2021;8:1148. doi: 10.3389/fvets.2021.746755.
Bradley A.J. Bovine mastitis: An evolving disease. Vet. J. 2002;164:116–128. doi: 10.1053/tvjl.2002.0724.
Krömker V., Leimbach S. Mastitis treatment—Reduction in antibiotic usage in dairy cows. Reprod. Domest. Anim. 2017;52:21–29. doi: 10.1111/rda.13032.
Cvetnić L., Samardžija M., Habrun B., Kompes G., Benić M. Microbiological monitoring of mastitis pathogens in the control of udder health in dairy cows. Slov. Vet. Res. 2016;53:131–140.
Costa E.O.d., Gandra C., Pires M., Coutinho S., Castilho W., Teixeira C. Survey of bovine mycotic mastitis in dairy herds in the State of São Paulo, Brazil. Mycopathologia. 1993;124:13–17. doi: 10.1007/BF01103051.
Prusa B. Alternative solutions to antibiotics in mastitis treatment for dairy cows-a review. Anim. Sci. Pap. Rep. 2020;38:117–133.
Hossain M, Paul S, Hossain M, Islam M, Alam M. Bovine mastitis and its therapeutic strategy doing antibiotic sensitivity test. Austin J Vet Sci Anim Husb. 2017;4:1030.
Fair RJ, Tor Y. Antibiotics and bacterial resistance in the 21st century. Perspect Medicin Chem 2014;6:25–64. Perspect Medicin Chem. 2014;6:25–64. doi: 10.4137/PMC.S14459
Suriyasathaporn W, Chupia V, Sing-Lah T, Wongsawan K, Mektrirat R, Chaisri W. Increases of antibiotic resistance in excessive use of antibiotics in smallholder dairy farms in northern Thailand. Asian-Australas J Anim Sci. 2012;25:1322–8. doi: 10.5713/ajas.2012.12023.
Prusa B. Alternative solutions to antibiotics in mastitis treatment for dairy cows-a review. Anim. Sci. Pap. Rep. 2020;38:117–133.
Kalińska A., Jaworski S., Wierzbicki M., Gołębiewski M. Silver and copper nanoparticles—An alternative in future mastitis treatment and prevention? Int. J. Mol. Sci. 2019;20:1672. doi: 10.3390/ijms20071672.
Lange A., Grzenia A., Wierzbicki M., Strojny-Cieslak B., Kalińska A., Gołębiewski M., Radzikowski D., Sawosz E., Jaworski S. Silver and copper nanoparticles inhibit biofilm formation by mastitis pathogens. Animals. 2021;11:1884. doi: 10.3390/ani11071884.
Hozyen H., Ibrahim E., Khairy E., El-Dek S. Enhanced antibacterial activity of capped zinc oxide nanoparticles: A step towards the control of clinical bovine mastitis. Vet. World. 2019;12:1225. doi: 10.14202/vetworld.2019.1225-1232.
Giraudo J.A., Calzolari A., Rampone H., Rampone A., Giraudo A.T., Bogni C., Larriestra A., Nagel R. Field trials of a vaccine against bovine mastitis. 1. Evaluation in heifers. J. Dairy Sci. 1997;80:845–853. doi: 10.3168/jds.S0022-0302(97)76006-5.
Nilsson A.S. Phage therapy—Constraints and possibilities. Upsala J. Med. Sci. 2014;119:192–198. doi: 10.3109/03009734.2014.902878.
Oechslin F. Resistance development to bacteriophages occurring during bacteriophage therapy. Viruses. 2018;10:351. doi: 10.3390/v10070351.
Groot M.J., Berendsen B.J., Cleton N.B. The Next Step to Further Decrease Veterinary Antibiotic Applications: Phytogenic Alternatives and Effective Monitoring; the Dutch Approach. Front. Vet. Sci. 2021;8:709750. doi: 10.3389/fvets.2021.709750.
Yap P.S.X., Lim S.H.E., Hu C.P., Yiap B.C. Combination of essential oils and antibiotics reduce antibiotic resistance in plasmid-conferred multidrug resistant bacteria. Phytomedicine. 2013;20:710–713. doi: 10.1016/j.phymed.2013.02.013.
Amber R., Adnan M., Tariq A., Khan S.N., Mussarat S., Hashem A., Al-Huqail A.A., Al-Arjani A.-B.F., Abd_Allah E.F. Antibacterial activity of selected medicinal plants of northwest Pakistan traditionally used against mastitis in livestock. Saudi J. Biol. Sci. 2018;25:154–161. doi: 10.1016/j.sjbs.2017.02.008.
Cheesman M.J., Ilanko A., Blonk B., Cock I.E. Developing new antimicrobial therapies: Are synergistic combinations of plant extracts/compounds with conventional antibiotics the solution? Pharmacogn. Rev. 2017;11:57. doi: 10.4103/phrev.phrev_21_17.
Zeise J., Fritz J. Use and efficacy of homeopathy in prevention and treatment of bovine mastitis. Open Agric. 2019;4:203–212. doi: 10.1515/opag-2019-0019.
Tomanić, D.; Samardžija, M.; Kovačević, Z. (2022). Alternatives to antimicrobial treatment in bovine mastitis therapy: a review. Antibiotics, 12, 683. https://doi.org/10.3390/antibiotics12040683
Li X., Xu C., Liang B., Kastelic J.P., Han B., Tong X., Gao J. (2023) Alternatives to antibiotics for treatment of mastitis in dairy cows. Frontiers in Veterinary Science, 10:1160350. https://doi.org/10.3389/fvets.2023.1160350
Cheng W.N., Han S.G. Bovine mastitis: Risk factors, therapeutic strategies, and alternative treatments – A review. Asian-Australas. J. Anim. Sci. 2020;33:1699–1713. doi: 10.5713/ajas.20.0156.
Paşca C, Mărghitaş L, Dezmirean D, et al. Medicinal plants based products tested on pathogens isolated from mastitis milk. Molecules. 2017;22:1473. doi: 10.3390/molecules22091473.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Authors
This work is licensed under a Creative Commons Attribution 4.0 International License.
